2012-09-01
Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: The nationwide emergence of a single sequence type
Publication
Publication
Clinical Microbiology and Infection , Volume 18 - Issue 9
Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010-2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n=70, 85%), identified as ST111 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
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| doi.org/10.1111/j.1469-0691.2012.03969.x, hdl.handle.net/1765/61136 | |
| Clinical Microbiology and Infection | |
| Organisation | Department of Medical Microbiology and Infectious Diseases |
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van der Bij, A., van der Zwan, D., Peirano, G., Severin, J., Pitout, J. D. D., van Westreenen, M., & Goessens, W. (2012). Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: The nationwide emergence of a single sequence type. Clinical Microbiology and Infection, 18(9). doi:10.1111/j.1469-0691.2012.03969.x |
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