2006-06-01
Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy
Publication
Publication
Journal of Neuroimmunology , Volume 175 - Issue 1-2 p. 152- 159
Antineural antibody activity is the implicated pathogenic mechanism in polyneuropathy associated with monoclonal gammopathy. Recognition of antigen depends on immunoglobulin variable regions, encoded by V genes. We studied VHDJH and VLJL gene use in monoclonal B cells by clonal analysis in 20 patients with polyneuropathy and IgM monoclonal gammopathy. V genes associated with bacterial responses appear over-represented and VH3-23 was preferentially used, without association with specific D, JH or VLJL. V genes revealed somatic mutation and intraclonal variation was found in 9 of 20 patients. Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells.
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doi.org/10.1016/j.jneuroim.2006.02.008, hdl.handle.net/1765/61378 | |
Journal of Neuroimmunology | |
Organisation | Department of Neurology |
Eurelings, M., Notermans, N., Lokhorst, H., van Kessel, B., Jacobs, B., Wokke, J., … Bloem, A. (2006). Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy. Journal of Neuroimmunology, 175(1-2), 152–159. doi:10.1016/j.jneuroim.2006.02.008 |