1991-04-01
Glafenine-associated anaphylaxis as a cause of hospital admission in The Netherlands
Publication
Publication
European Journal of Clinical Pharmacology , Volume 40 - Issue 4 p. 367- 371
Summary.
In 1981 generalized anaphylaxis was registered
on 166 occasions in Dutch general and academic hospitals.
Clinical details of 120 of those patients revealed that in 107
anaphylaxis was either probable (n=90) or possible
(n = 17), whereas in 13 cases some other reaction than anaphylaxis
had occurred. The series of confirmed cases
contained 46 men and 61 women, with mean ages of 47 y
and 48 y, respectively.
There was a complete recovery in 102 patients and two
patients died. Hypotension was present in 79 cases (74%),
dyspnoea in 34 cases (32%) and a skin reaction, mainly urticaria,
erythema or angioedema, was mentioned in
62 cases (58%). Most cases of anaphylaxis were drug-induced
(76%), the main causes being the analgesic glafenine
and contrast media. Glafenine was mentioned as
the cause in 36% of all admissions for drug-induced anaphylaxis.
Only 3.7% of cases had been reported to the
voluntary reporting scheme of the Netherlands Centre for
Monitoring of Adverse Reactions to Drugs.
On the basis of reimbursement data, the risk of developing
severe anaphylaxis to glafenine was estimated at
11.7-19.3-fold relative to indomethacin, and 13.4-20.2-
fold relative to oral penicillins.
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doi.org/10.1007/BF00265845, hdl.handle.net/1765/62543 | |
European Journal of Clinical Pharmacology | |
Organisation | Department of Internal Medicine |
Stricker, B., de Groot, R., & Wilson, P. (1991). Glafenine-associated anaphylaxis as a cause of hospital admission in The Netherlands. European Journal of Clinical Pharmacology, 40(4), 367–371. doi:10.1007/BF00265845 |