1996-05-02
CD20 and CD40 mediated mitogenic responses in B-lineage acute lymphoblastic leukaemia
Publication
Publication
British Journal of Haematology , Volume 93 - Issue 1 p. 125- 130
Activation of CD20, a cross-membrane ion channel, induces cell cycle progression from G0 to G1 in B lymphocytes. Subsequent activation of CD40, a membrane receptor of the nerve growth factor receptor superfamily, transits the B cells to the S phase. CD40 may also act synergistically in combination with IL-4 (B lymphocytes) or IL-3/IL-7 (B-cell precursors). We investigated the proliferative responses of B-lineage acute lymphoblastic leukaemia (ALL) cells to CD20/CD40 activation. In 18/56 ALL cases, CD20 activation resulted in significant increases in DNA synthesis. Similar, although more moderate, effects were seen of activation of CD40 in 10/44 cases. Responses to CD20 or CD40 activation were independent of co-stimulation with IL-3, IL-4 or IL-7, and various cocktails of the different growth stimuli did not act synergistically.
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| doi.org/10.1046/j.1365-2141.1996.4781011.x, hdl.handle.net/1765/63452 | |
| British Journal of Haematology | |
| Organisation | Department of Hematology |
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Smiers, F., van Paassen, M., Hählen, K., Löwenberg, B., & Touw, I. (1996). CD20 and CD40 mediated mitogenic responses in B-lineage acute lymphoblastic leukaemia. British Journal of Haematology, 93(1), 125–130. doi:10.1046/j.1365-2141.1996.4781011.x |
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