Tumor-associated macrophages in thoracic malignancies

Lievense, Sanne; Bezemer, Koen; Aerts, Joachim; Hegmans, Joost

doi:10.1016/j.lungcan.2013.02.017

L.A. Lievense (Sanne), K. Bezemer (Koen), J.G.J.V. Aerts (Joachim) and J.P.J.J. Hegmans (Joost)

2013-06-01

Tumor-associated macrophages in thoracic malignancies

Lung Cancer , Volume 80 - Issue 3 p. 256- 262

Tumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest. In this review we will discuss the importance of TAMs in the pathogenesis and clinical outcome of lung cancer and mesothelioma patients. In addition, the potential of TAMs as therapeutic targets will be discussed.

Additional Metadata
Keywords	Immuno-oncology, Immunotherapy, Lung cancer, Mesothelioma, Personalized medicine, Tumor microenvironment
Persistent URL	doi.org/10.1016/j.lungcan.2013.02.017, hdl.handle.net/1765/69725
Journal	Lung Cancer
Organisation	Department of Pulmonology
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	Lievense, S., Bezemer, K., Aerts, J., & Hegmans, J. (2013). Tumor-associated macrophages in thoracic malignancies. Lung Cancer (Vol. 80, pp. 256–262). doi:10.1016/j.lungcan.2013.02.017

Tumor-associated macrophages in thoracic malignancies

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