Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients
Topical 2% mupirocin ointment eradicated chronic Staphylococcus aureus nasal carriage immediately post-therapy in 17 (77%) of 22 haemodialysis patients. Mean time to recurrence was 3.8 weeks. Similar pre-therapy and post-therapy phage types occurred in 12 (71%) of 17 patients. Staphylococcus aureus infections developed in none of 17 successfully treated patients, two of five treatment failures (P = 0.05), and 10 of 46 untreated patients studied concurrently (P = 0.03).
|Keywords||antibiotics/therapeutic use, carrier state/microbiology, fatty acids/therapeutic use, human, mupirocin, nasal ucosa/microbiology, oitments, pilot projects, recurrence, renal dialysis, staphylococcus aureus/drug effects/growth & development, support, non-U.S. government|
L. Holton, D., E. Nicolle, L., Diley, D., & Bernstein, K.. (1991). Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients. Journal of Hospital Infection, 17(2), 133–137. Retrieved from http://hdl.handle.net/1765/6980