Plasticity in eye movement control

The cerebellum plays an important role in the recalibration and adaptive adjustment of movements, as well as learning new motor skills and motor related associations. In this thesis, we investigated the mechanisms underlying cerebellar motor learning. To obtain a better understanding, in how the cerebellum processes and stores information, we used specific perturbations that affected the information processing of the cerebellum. Signal transduction pathways were affected that were considered important for cerebellar motor learning by using genetic tools (transgenic mice) and the application of antibodies. Alterations in cerebellar motor learning were studied by monitoring the oculomotor system of these transgenic and treated mice.