Hepatitis E prevalence among HIV infected patients with elevated liver enzymes in the Netherlands

Background: In recent years chronic hepatitis E virus (HEV) infections have been reported in immunosuppressed patients, including HIV-positive patients with low CD4 cell counts. Because of delayed anti-HEV seroconversion in patients with CD4 cell count. <. 200. cells/ml it is difficult to draw firm conclusions on HEV-seroprevalence in a population of HIV positive patients. Objectives: To determine the HEV seroprevalence in a population of HIV infected patients. Study design: We retrospectively analysed the HEV prevalence in a population of 256 HIV infected patients with liver enzyme elevations (LEEs), using HEV specific antibody testing and HEV-RNA detection. Results: Within this cohort we observed a HEV-seroprevalence of 11.7%, without any anti-HEV IgM positive or HEV-RNA positive cases. HEV seropositivity was equally prevalent among different CD4+ cell count groups. Conclusion: Although HIV infected patients in the Netherlands are at risk of acquiring HEV, the number of acute infections is low and no chronic cases were found.