1997-04-01
Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease
Publication
Publication
Journal of Neuroimmunology , Volume 74 - Issue 1-2 p. 55- 61
We studied an autoantibody (called anti-Tr), found in the serum and CSF of five patients with paraneoplastic cerebellar degeneration (PCD) and Hodgkin's disease (HD). Anti-Tr antibodies labelled the cytoplasm of Purkinje cells of human and rat cerebellum. The molecular layer of rat cerebellum showed a characteristic dotted pattern suggestive of immunoreactivity of dendritic spines of Purkinje cells. Patients with cerebellar disorders without HD (159) or HD without PCD (30) did not harbor anti-Tr antibodies. Immunoblots of human Purkinje cells or rat and mouse cerebellum were negative. Anti-Tr antibodies, as defined in this study, appear specific for HD-associated PCD. The immunohistochemical pattern described in the rat cerebellum coupled with the absence of reactivity in the immunoblot may be used to identify anti-Tr antibodies.
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doi.org/10.1016/S0165-5728(96)00205-6, hdl.handle.net/1765/70632 | |
Journal of Neuroimmunology | |
Organisation | Department of Neurology |
Graus, F., Dalmau, J., Valldeoriola, F., Ferrer, I., Reñé, R., Marin, M., … Moll, W. (1997). Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. Journal of Neuroimmunology, 74(1-2), 55–61. doi:10.1016/S0165-5728(96)00205-6 |