2004-12-01
Imaging of small vessels using photoacoustics: An in vivo study
Publication
Publication
Lasers in Surgery and Medicine , Volume 35 - Issue 5 p. 354- 362
Background and Objectives: The ability to correctly visualize the architectural arrangement of microvasculature is valuable to many diverse fields in medicine. In this study, we applied photoacoustics (PA) to obtain high-resolution images of submillimeter blood vessels. Study Design/Materials and Methods: Short laser pulses are used to generate ultrasound from superficial blood vessels in several animal models. From these ultrasound waves the interior of blood vessels can be reconstructed. Results: We present results from a novel approach based on the PA principle that allows specific in vivo visualization of dermal blood vessels without the use of contrast agents or ionizing radiation. Conclusions: We show PA images of externalized blood vessels and demonstrate in vivo PA imaging of vasculature through layers of skin varying in thickness.
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doi.org/10.1002/lsm.20100, hdl.handle.net/1765/70777 | |
Lasers in Surgery and Medicine | |
Organisation | Department of Plastic and Reconstructive Surgery |
Siphanto, R., Kolkman, R. G., Huisjes, A., Pilatou, M., de Mul, F., Steenbergen, W., & van Adrichem, L. (2004). Imaging of small vessels using photoacoustics: An in vivo study. Lasers in Surgery and Medicine, 35(5), 354–362. doi:10.1002/lsm.20100 |