2012-10-01
Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?
Publication
Publication
Dermatology: international journal for clinical and investigative dermatology , Volume 225 - Issue 1 p. 9- 13
The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of γ-secretase mutations in a subpopulation of patients with HS suggested γ-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic γ-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model. Copyright
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doi.org/10.1159/000339773, hdl.handle.net/1765/71306 | |
Dermatology: international journal for clinical and investigative dermatology | |
Organisation | Department of Dermatology |
van der Zee, H., Laman, J., & Prens, E. (2012). Can animal skin diseases or current transgenic mice serve as a model for hidradenitis suppurativa?. Dermatology: international journal for clinical and investigative dermatology (Vol. 225, pp. 9–13). doi:10.1159/000339773 |