2002-05-04
Prolonged use of proton pump inhibitors, CagA status, and the outcome of Helicobacter pylori gastritis
Publication
Publication
Journal of Clinical Gastroenterology , Volume 34 - Issue 5 p. 536- 540
Goals and Background: To assess whether prolonged use of proton pump inhibitors (PPIs) in patients infected with Helicobacter pylori has adverse effects on gastritis. Study: We studied 34 H. pylori-positive individuals with reflux esophagitis, Barrett esophagus, or nonulcer dyspepsia. Half of them were on maintenance treatment with PPIs (mean, 8 years) and half were not. H. pylori and CagA status were tested serologically. Gastric biopsies were classified histopathologically by the updated Sydney classification. Results: Proton pump inhibitors in H. pylori gastritis are associated with significantly less antral inflammation and lower H. pylori density, regardless of CagA status. There was a tendency toward more antral atrophy in patients with the CagA strain who were undergoing maintenance treatment with PPIs (p = 0.08), but there was an opposite tendency in CagA-negative individuals (p = 0.08). Intestinal metaplasia was seen more frequently in CagApositive, treated individuals (p = 0.028). Conclusions: These findings support the hypothesis that CagA status is important in the progression to atrophy and that maintenance treatment with PPIs accelerate this progression, while reducing inflammatory infiltration.
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doi.org/10.1097/00004836-200205000-00011, hdl.handle.net/1765/72624 | |
Journal of Clinical Gastroenterology | |
Organisation | Department of Pathology |
Gudlaugsdottir, S., van Dekken, H., Stijnen, T., & Wilson, P. (2002). Prolonged use of proton pump inhibitors, CagA status, and the outcome of Helicobacter pylori gastritis. Journal of Clinical Gastroenterology, 34(5), 536–540. doi:10.1097/00004836-200205000-00011 |