2004-11-01
Detection of Helicobacter pylori in bile of cats
Publication
Publication
F E M S Immunology and Medical Microbiology , Volume 42 - Issue 3 p. 307- 311
Lymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive (p=0.44). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir.
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| doi.org/10.1016/j.femsim.2004.06.002, hdl.handle.net/1765/73121 | |
| F E M S Immunology and Medical Microbiology | |
| Organisation | Department of Gastroenterology & Hepatology |
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Boomkens, H., Kusters, J., Hoffmann, G., Pot, R., Spee, B., Penning, C., … Rothuizen, J. (2004). Detection of Helicobacter pylori in bile of cats. F E M S Immunology and Medical Microbiology, 42(3), 307–311. doi:10.1016/j.femsim.2004.06.002 |
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