2006
Interactions between five candidate genes and antihypertensive drug therapy on blood pressure
Publication
Publication
The Pharmacogenomics Journal , Volume 6 - Issue 1 p. 22- 26
Despite the availability of effective antihypertensive drugs, there is a large variation in response to these drugs. This study investigates whether polymorphisms in the angiotensin converting enzyme (I/D), angiotensinogen (M235T), α-adducin (G460W), angiotensin II type 1 receptor (1166A/C), or G protein β3-subunit (825C/T) gene modify the mean difference in blood pressure levels among diuretics, β-blockers, or ACE-inhibitors users. Data were used from the Doetinchem Cohort Study, and blood pressure data were collected from GPs (1987-1997). A marginal generalized linear model (GEE) was used to assess the gene-drug interaction on the mean difference in systolic/diastolic blood pressure. In total, 625 hypertensive individuals were included with a total of 5262 measurements of blood pressure. Only the interaction between diuretic use and the GNB3 825C/T polymorphism was significant (C allele versus TT systolic blood pressure (SBP): 4.33 mmHg [95% CI: 0.14-8.54]). Thus, the mean SBP level among diuretic users may be modified by the GNB3 825C/T polymorphism.
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| doi.org/10.1038/sj.tpj.6500339, hdl.handle.net/1765/73446 | |
| The Pharmacogenomics Journal | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Schelleman, H., Stricker, B., Verschuren, W. M. M., de Boer, A., Kroon, B., de Leeuw, P., … Klungel, O. (2006). Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. The Pharmacogenomics Journal, 6(1), 22–26. doi:10.1038/sj.tpj.6500339 |
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