2004-10-15
The active spatial organization of the β-globin locus requires the transcription factor EKLF
Publication
Publication
Genes & Development , Volume 18 - Issue 20 p. 2485- 2490
Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the β-globin locus. When actively expressed, the cis-regulatory elements of the β-globin locus are in proximity in the nuclear space, forming a compartment termed the Active Chromatin Hub (ACH). However, it is unknown which proteins are involved in ACH formation. Here, we show that EKLF, an erythroid transcription factor required for adult β-globin gene transcription, is also required for ACH formation. We conclude that transcription factors can play an essential role in the three-dimensional organization of gene loci.
Additional Metadata | |
---|---|
, , , , , | |
doi.org/10.1101/gad.317004, hdl.handle.net/1765/74009 | |
Genes & Development | |
Organisation | Biophysical Genomics, Department Cell Biology & Genetics |
Drissen, R., Palstra, R.-J., Gillemans, N., Splinter, D., Grosveld, F., Philipsen, S., & de Laat, W. (2004). The active spatial organization of the β-globin locus requires the transcription factor EKLF. Genes & Development, 18(20), 2485–2490. doi:10.1101/gad.317004 |