2012
The chromosome 9 ALS and FTD locus is probably derived from a single founder
Publication
Publication
Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology , Volume 33 - Issue 1
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
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| doi.org/10.1016/j.neurobiolaging.2011.08.005, hdl.handle.net/1765/74093 | |
| Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology | |
| Organisation | Department of Neurology |
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Mok, K., Traynor, B., Schymick, J., Tienari, P., Laaksovirta, H., Peuralinna, T., … Hardy, J. (2012). The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 33(1). doi:10.1016/j.neurobiolaging.2011.08.005 |
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