2014-12-12
MicroRNAs, the DNA Damage Response and Cancer
Publication
Publication
MicroRNAs, de DNA Schade Respons en Kanker
Abstract
DNA encodes all developmental instructions and heritable traits of an organism, organized in discrete units called genes. According to the central dogma of gene expression, genes are transcribed into mRNAs, which are translated into proteins that perform physical roles in a cell. However, genes can also express non-protein-coding RNAs that influence expression levels of protein-coding genes. Both protein-coding and non-protein-coding genes determine structure, function and fate of each cell and thereby shape the whole organism. It is therefore of vital importance that DNA integrity is maintained to secure functional gene transcription. In addition, DNA integrity is also required to faithfully replicate the genome to enable cellular proliferation, organismal development and reproduction.
| Additional Metadata | |
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| , , , | |
| J.H.J. Hoeijmakers (Jan) | |
| Erasmus University Rotterdam | |
| The research described in this thesis has been financially supported by the Dutch Cancer Society and an Erasmus MC mRace grant and was performed at the Department of Genetics of the Erasmus Medical Center, Rotterdam, the Netherlands. The department is part of the Medical Genetics Centre South-west Holland. | |
| hdl.handle.net/1765/77252 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Wouters, M. (2014, December 12). MicroRNAs, the DNA Damage Response and Cancer. Retrieved from http://hdl.handle.net/1765/77252 |
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