Modulography: elasticity imaging of atherosclerotic plaques
Modulography is an experimental elasticity imaging method. It has potential to become an all-in-one in vivo tool (a) for detecting vulnerable atherosclerotic coronary plaques, (b) for assessing information related to their rupture-proneness and (c) for imaging their elastic material composition. Modulography determines a cross-sectional image of the elasticity distribution (=Young's modulus) from deformation (=strain) that is processed from intravascular ultrasound (IVUS) measurements. By looking at this image, cardiologists and other researchers can directly identify and characterize soft and stiff plaque-components of thin-cap fibroatheromas and of heterogeneous plaques. As a diagnostic and pharmaceutical screening tool, Modulography may contribute to the reduction of heart attacks and strokes, which are the number-one killers in westernized societies.
|Keywords||atherosclerosis, elasticity, intravascular ultrasound (IVUS), inverse problem, tissue characterization, vulnerable plaque|
|Promotor||Serruys, P.W.J.C. (Patrick)|
|Sponsor||Bristol-Myers Squibb & Bristol-Myers Squibb MedicalImaging Cardialysis , Dutch Technology Foundation (STW) , Interuniversity Cardiology Institute of the Netherlands , Merck Sharp & Dohme BV , Netherlands Heart Foundation , Novartis Pharma AG , OrbusNeich , Pfizer , Sanofi-Aventis , Serruys, Prof. Dr. P.W.J.C. (promotor) , Steen, Prof. Dr. A.W.F. van der (promotor) , Volcano Corporation|
Baldewsing, R.. (2006, June 21). Modulography: elasticity imaging of atherosclerotic plaques. Retrieved from http://hdl.handle.net/1765/7922