Clinical & biochemical characterization of gastroenteropancreatic neuroendocrine tumors

NETs form a heterogeneous group of relatively rare tumors with a fair degree of variability in clinical manifestations and biological behavior. The primary tumor site localizations of the majority of metastatic NETs are the gastrointestinal (GI) and bronchopulmonary tracts, and the pancreas. GEP-NETs originating from cells of the diffuse neuroendocrine system of the GI tract and pancreas have shown an increasing incidence and prevalence over the past 30 years.
This thesis evaluates the clinical and biochemical characteristics of GEP-NETs, and includes data on the safety and efficacy of different sequential treatments.