Bench-to-bedside review: genetic influences on meningococcal disease
This review discusses the possible involvement of a variety of genetic polymorphisms on the course of meningococcal disease. It has been shown that several common genetic polymorphisms can either influence the susceptibility to meningococcal disease or can account for a higher mortality rate in patients. Gene polymorphisms concerning antibody receptors, lipopolysaccharide (LPS) binding receptors or proteins, innate complement proteins as well as cytokines and hemostatic proteins are described. The study of genetic polymorphisms might provide important insights in the pathogenesis of meningococcal disease and could make it possible to identify individuals who are at risk of either contracting or dying from meningococcal disease.
|Keywords||Adolescent, Adult, Child, Preschool, Complement System Proteins/deficiency, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1/genetics, Interleukin-6/genetics, Lectins/genetics, Meningococcal Infections/*genetics/immunology/mortality, Middle Aged, Neisseria meningitidis/immunology, Phagocytosis, Plasminogen Activator Inhibitor 1/genetics, Polymorphism, Genetic, Receptors, IgG/genetics/immunology, Risk Factors, Signal Transduction, Tumor Necrosis Factor-alpha/genetics|
Vermont, C.L., Hazelzet, J.A., & de Groot, R.. (2002). Bench-to-bedside review: genetic influences on meningococcal disease. Critical Care (Print). Retrieved from http://hdl.handle.net/1765/8280