Revisiting the clinical validity of multiplex genetic testing in complex diseases
The usefulness of genetic testing to identify high-risk patients for common multifactorial diseases is subject to debate. Optimism about the public health opportunities is counterbalanced with skepticism, since genetic factors appear to play a role in only a minority of patients with complex diseases, the number of genes involved is large, and their penetrance is incomplete (Holtzman and Marteau 2000; Vineis et al. 2001).
|Keywords||Genetic Screening, Humans, Multifactorial Inheritance, Research Support, Non-U.S. Gov't|
Janssens, A.C.J.W., Pardo Silva, M.C., Steyerberg, E.W., & van Duijn, C.M.. (2004). Revisiting the clinical validity of multiplex genetic testing in complex diseases. American Journal of Human Genetics, 585–588. Retrieved from http://hdl.handle.net/1765/8493