OBJECTIVE: A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. METHODS: Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene. RESULTS: The IGF-1 locus was significantly associated with the presence of ROA (over-all adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). CONCLUSION: These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.

Additional Metadata
Keywords Aged, Alleles, Body Mass Index, Bone Density, Female, Genotype, Humans, Insulin-Like Growth Factor I/*genetics, Male, Middle Aged, Osteoarthritis/*genetics/physiopathology/radiography, Prospective Studies, Research Support, Non-U.S. Gov't
Persistent URL dx.doi.org/10.1136/ard.57.6.371, hdl.handle.net/1765/8513
Citation
Meulenbelt, I., Bijkerk, C., Miedema, H.S., Breedveld, F.C., Valkenburg, H.A., Pols, H.A.P., … Hofman, A.. (1998). A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study). Annals of the Rheumatic Diseases: an international peer-reviewed journal for health professionals and researchers in the rheumatic diseases, 57(6), 371–374. doi:10.1136/ard.57.6.371