Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide
The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae septicemia resulting from intraperitoneal bacterial inoculation was investigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPPE) or 40% (LE-MTPPE), whereas untreated control mice died. Only repeated prophylactic treatment with LE-MTPPE could further increase survival up to 85%.
|Keywords||Adjuvants, Immunologic/administration & dosage/*therapeutic use, Animals, Bacteremia/complications/*drug therapy/microbiology, Colony Count, Microbial, Cyclophosphamide, Drug Carriers, Klebsiella Infections/complications/*drug therapy/microbiology, Klebsiella pneumoniae/*drug effects, Leukopenia/chemically induced/*complications, Liposomes, Male, Mice, Mice, Inbred C57BL, Phosphatidylethanolamines/administration & dosage/*therapeutic use|
Melissen, P.M., van Vianen, W., & Bakker-Woudenberg, I.A.J.M.. (1994). Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide. Antimicrobial Agents and Chemotherapy. Retrieved from http://hdl.handle.net/1765/8589