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P.A. in 't Veld, F.J.M. Broekmans (Frank), H.F. de France, P.L. Pearson, M.H. Pieters and R.J. van Kooij

1997

Intracytoplasmic sperm injection (ICSI) and chromosomally abnormal spermatozoa

Publication

Publication

Human Reproduction

An infertile couple was referred for intracytoplasmic sperm injection (ICSI) because of primary infertility and oligoasthenoteratozoospermia (OAT) in the male. It was observed that although the sperm cells presented with an unusual head size and multiple tails they were able to fertilize the oocytes after ICSI. Subsequent molecular cytogenetic analysis demonstrated de-novo chromosome abnormalities in virtually all sperm cells with 40% diploidy and 24% triploidy in addition to aneuploidy for the sex chromosomes.

Additional Metadata
Keywords *Chromosome Aberrations, *Chromosome Disorders, *Sperm-Ovum Interactions, Adult, Cytoplasm, Female, Fertilization in Vitro/*methods, Genotype, Humans, In Situ Hybridization, Fluorescence, Infertility, Male/*genetics, Male, Microinjections, Oligospermia/genetics, Phenotype
Persistent URL hdl.handle.net/1765/8687
Journal Human Reproduction
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
in 't Veld, P. A., Broekmans, F., de France, H. F., Pearson, P. L., Pieters, M. H., & van Kooij, R. J. (1997). Intracytoplasmic sperm injection (ICSI) and chromosomally abnormal spermatozoa. Human Reproduction. Retrieved from http://hdl.handle.net/1765/8687
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