Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice
In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg . day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.
|Keywords||Amphotericin B/*administration & dosage/blood, Animals, Antibiotics, Antifungal/*administration & dosage, Candidiasis/*drug therapy, Drug Carriers, Leukopenia/*complications, Liposomes, Mice|
van Etten, E.W.M., Snijders, S.V., van Vianen, W., & Bakker-Woudenberg, I.A.J.M.. (1998). Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice. Antimicrobial Agents and Chemotherapy. Retrieved from http://hdl.handle.net/1765/8898