1999
Oral vitamins C and E as additional treatment in patients with acute anterior uveitis
Publication
Publication
A randomised double masked study in 145 patients
AIM: To investigate the effect of additional oral vitamins C and E on
acute anterior uveitis.
METHODS: A placebo controlled double masked study
on the effect of vitamin C 500 mg in combination with vitamin E 100 mg
twice daily in 145 patients with acute anterior uveitis. As a primary end
point variable, laser cell/flare measurements were performed. Best
corrected and stenopeic visual acuity (VA) testing and clinical variable
scores were measured.
RESULTS: Laser flare measurements (ph/s) before
treatment were 207.1 (SD 258) in the vitamin group and 143.6 (156) in the
placebo group. After 3 days corresponding values were 80.2 (129) and 54.7
(82), after 7 days 89.2 (187) (12.5) and 85.8 (208), after 14 days 47.1
(109.5) and 40.5 (116) after 28 days 23.1 (53.6) and 23.1 (48), and after
56 days 15.6 (26) and 15.3 (17). There was no significant difference in
time trend between the two treatment groups (RMANOVA; p = 0.53). Baseline
VA (logMAR) was 0.106 (0.241) in the vitamin group and 0.128 (0.456) in
the placebo group. VA after 3 days was 0. 236 (0.293) and 0.344 ( 0.489),
after 7 days 0.204 (0.292) and 0.292 (0.479), after 14 days 0.162 (0.274)
and 0.193 (0.454), after 28 days 0.096 (0.232) and 0.158 (0.436), and
0.026 (0.213) and 0.106 (0. 437) after 56 days. Although no significant
difference in time trend was detected, evaluation of the VA data of the
last time point (56 days) by means of the Mann-Whitney test showed a
significantly better VA in the vitamin group (p = 0.01).
CONCLUSIONS: There was no significant effect of vitamins C and E on laser flare
measurements. The significant effect of the oral vitamins on visual acuity
at 8 weeks after start of the oral vitamins C and E may indicate a
protective effect in patients with acute anterior uveitis.
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hdl.handle.net/1765/9188 | |
British Journal of Ophthalmology: a peer review journal for health professionals and researchers in ophthalmology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
van Rooij, J., thoe Schwartzenberg, S., Baarsma, S., & Mulder, P. (1999). Oral vitamins C and E as additional treatment in patients with acute anterior uveitis. British Journal of Ophthalmology: a peer review journal for health professionals and researchers in ophthalmology. Retrieved from http://hdl.handle.net/1765/9188 |