2016-11-09
Restore the Balance : Side effects of dexamethasone in children with acute lymphoblastic leukemia
Publication
Publication
Herstel de balans : bijwerkingen van dexamethason in kinderen met acute lymfatische leukemie
The aim of this study was threefold:
· The primary aim was to reduce dexamethasone-induced cerebral side effects on mood, behavior, sleep, and cognition by an intervention with physiological doses of cortisol.
· The secondary aim was to study whether dexamethasone-induced metabolic toxicity (i.e. hyperglycemia, insulin resistance, visceral fat gain, hypertension and hypercholesterolemia) occurred less frequently during intervention treatment compared to placebo.
· The third aim was to study the positive predictive value of a novel in vivo diagnostic test (salivary very low dose dexamethasone suppression test) on dexamethasone side effects.
| Additional Metadata | |
|---|---|
| R. Pieters (Rob) , M.M. van den Heuvel-Eibrink (Marry) , E.L.T. van den Akker (Erica) | |
| Erasmus University Rotterdam | |
| The work described in this thesis was funded by Stichting Kinderen Kankervrij (KiKa) (Project 99). Printing of this thesis was financially supported by Nutricia Early Life Nutrition and Pfizer. | |
| hdl.handle.net/1765/93913 | |
| Organisation | Department of Pediatrics |
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Warris, L. (2016, November 9). Restore the Balance : Side effects of dexamethasone in children with acute lymphoblastic leukemia. Retrieved from http://hdl.handle.net/1765/93913 |
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