Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years
OBJECTIVE: To assess the effect of age on clinical, endocrine and sonographic features associated with polycystic ovary syndrome (PCOS) in normogonadotrophic anovulatory infertile women of reproductive years. DESIGN: Cross-sectional study. METHODS: Four hundred and seventy-two oligo-amenorrhoeic infertile patients, presenting with normal FSH and oestradiol concentrations, aged 17-42 years underwent a standardised initial evaluation including: cycle history, body mass index, waist-to-hip ratio and transvaginal ultrasound scanning of ovaries. Fasting blood samples were obtained for extensive endocrine evaluation. Cycle duration, serum levels of gonadotrophins, androgens, oestradiol, insulin, glucose, inhibin B as well as mean number of follicles, ovarian volume and ovarian stroma echogenicity were assessed. RESULTS: Older women had significantly lower LH and androgen and inhibin B serum levels. Similarly, older women presented with a reduced number of ovarian follicles. Age was inversely correlated with cycle duration (r=-0.112, P=0.02), LH (r=-0.154, P=0.001), testosterone (r=-0.194, P=0.001), androstenedione (r=-0.170, P=0.001), dehydroepiandrosterone (r=-0.157, P=0.001), insulin (r=-0.126, P=0.02), inhibin B (r=-0.118, P=0.03) serum levels and mean follicle number (r=-0.100, P=0.03). A positive correlation was observed between age and glucose to insulin ratio (r=0.138, P=0.009). CONCLUSIONS: Advanced age in normogonadotrophic anovulatory infertile women is associated with lower LH and androgen levels and with a decreased number of ovarian follicles. Although during reproductive years observed differences are relatively small, these age-related changes may affect the observed incidence of PCOS.
|Keywords||*Aging, Adolescent, Adult, Amenorrhea/complications, Androstenedione/blood, Body Constitution, Body Mass Index, Comparative Study, Cross-Sectional Studies, Dehydroepiandrosterone/blood, Fasting, Female, Follicle Stimulating Hormone/blood, Gonadotropins, Pituitary/*blood, Humans, Infertility, Female/*etiology, Inhibins/blood, Insulin/blood, Luteinizing Hormone/blood, Menstrual Cycle, Oligomenorrhea/complications, Ovarian Follicle/ultrasonography, Ovary/ultrasonography, Polycystic Ovary Syndrome/complications/*diagnosis/physiopathology, Research Support, Non-U.S. Gov't, Testosterone/blood|
Bili, H., Imani, B., Eijkemans, M.J.C., Fauser, B.C.J.M., & Laven, J.S.E.. (2001). Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years. European Journal of Endocrinology. Retrieved from http://hdl.handle.net/1765/9796