Bacterial cholangitis causing secondary sclerosing cholangitis: a case report
BACKGROUND: Although bacterial cholangitis is frequently mentioned as a cause of secondary sclerosing cholangitis, it appears to be extremely rare, with only one documented case ever reported. CASE PRESENTATION: A 48-year-old woman presented with an episode of acute biliary pancreatitis that was complicated by pancreatic abcess formation. After 3 months she had an episode of severe pyogenic (E. Coli) cholangitis that recurred over the subsequent 7 months on a further two occasions. Initially, cholangiography suggested the presence of extra-biliary intrahepatic abcesses while repeated investigations demonstrated development of multiple segmental biliary duct strictures. After maintenance antibiotic treatment was started, no episodes of cholangitis occurred over a 14-month period. CONCLUSIONS: Sclerosing cholangitis can rapidly develop after an episode of bacterial cholangitis. Extra-biliary involvement of the hepatic parenchyma with abcess formation may be a risk factor for developing this rare but particularly severe complication.
|Keywords||Abdominal Abscess/*complications, Cholangiopancreatography, Endoscopic Retrograde, Cholangitis, Sclerosing/*etiology/microbiology/radiography, Cholangitis/*complications/microbiology, Escherichia coli Infections/*complications/*diagnosis, Female, Humans, Liver Diseases/*complications, Middle aged, Pancreatic Diseases/*complications|
van Buuren, H.R., Depla, A.C.T.M., & ter Borg, P.C.J.. (2002). Bacterial cholangitis causing secondary sclerosing cholangitis: a case report. B M C Gastroenterology. Retrieved from http://hdl.handle.net/1765/9917