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and
T.O. Kilpeläinen (Tuomas)
2017-04-01
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Publication
Publication
PL o S Genetics (Online) , Volume 13 - Issue 4
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Additional Metadata | |
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Persistent URL | doi.org/10.1371/journal.pgen.1006528, hdl.handle.net/1765/99588 |
Journal | PL o S Genetics (Online) |
Grant | This work was funded by the European Commission 7th Framework Programme; grant id fp7/277849 - European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing (EURHEALTHAGEING), This work was funded by the European Commission 7th Framework Programme; grant id fp7/313010 - BBMRI - Large Prospective Cohorts (BBMRI-LPC), This work was funded by the European Commission 7th Framework Programme; grant id fp7/201413 - European Network for Genetic and Genomic Epidemiology (ENGAGE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/279143 - Identification of epigenetic markers underlying increased risk of T2D in South Asians (EPI-MIGRANT), This work was funded by the European Commission 7th Framework Programme; grant id fp7/201668 - European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO), This work was funded by the European Commission 7th Framework Programme; grant id fp7/305739 - Personalized diagnostics and treatment of high risk coronary artery disease patients. (RISKYCAD) |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Citation |
Graff, M. J. L., Scott, R., Justice, A., Young, K.L. (Kristin L.), Feitosa, M. F., Barata, L. (Llilda), … Kilpeläinen, T. (2017). Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PL o S Genetics (Online), 13(4). doi:10.1371/journal.pgen.1006528 |