Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms
January 2006
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BACKGROUND: Extrapyramidal syndromes (EPS) are clinically relevant side effects of metoclopramide which are often not anticipated. PATIENTS AND METHODS: Two patients who received metoclopramide developed an acute dystonic reaction. Symptoms disappeared after biperiden or trihexyphenidyl were given. Molecular analysis of the CYP2D6 gene was performed using a PCR-based method. RESULTS: Both patients were homozygous for inactive CYP2D6 alleles (CYP2D6*4/*4 and CYP2D6*4/*5), which are associated with slow drug metabolism. CONCLUSION: Metoclopramide-induced acute dystonic reactions may occur in patients carrying a CYP2D6 genetic polymorphism.
Keywords
- Male
- Adult
- Female
- Humans
- Acute Disease
- Syndrome
- Polymorphism, Genetic
- Cytochrome P-450 CYP2D6/*genetics/metabolism
- Dopamine Antagonists/*adverse effects
- Dystonia/*chemically induced/genetics
- Lymphoma, Non-Hodgkin/drug therapy
- Metoclopramide/*adverse effects
- Leukemia, Myeloid/drug therapy
Automatically Extracted Terms
- metoclopramide
- dystonic reaction
- cyp 2d
- patient
- reaction
- dystonic
- effect
- symptom
- receptor
- allele
- dopamine
- nausea
- antagonist
- metaboliser
- extrapyramidal
- dystonic reactions
- dopamine antagonist
- cyp 2d alleles
- antiemetic
- 5- ht 3-antagonists
