Pterins and affective disorders
(Pterinen en stemmingsstoornissen)
2007-09-19
Doctoral Thesis
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The pathophysiology of affective disorders is largely unknown. In patients with various affective disorders the activity of pterins and related amino acids were investigated before and after clinical treatment. In particular the bipolar affective disorder could be characterized by less activity of tetrahydrobiopterin resulting in decreased synthesis of nitric oxide. After clinical recovery the same results were seen implicating that disturbances in the pterin metabilism could reflect a vulnerability for mood disorders.
Supervisor
(promotor):
The
author
wishes to thank:
StichtingJos Schaap-Feering, Rotterdam, the Netherlands
Verhoeven,. Prof. Dr. W.M.A. (promotor
Keywords
- depression
- bipolar disorder
- mania
- nitric oxide
- tetrahydrobiopterin
- arginine
- electroconvulsive therapy
- nepterin
- seasonal affective disorder
Automatically Extracted Terms
- patient
- disorder
- biopterin
- neopterin
- level
- plasma
- affective
- depression
- tryptophan
- bipolar
- control
- affective disorders
- treatment
- group
- ratio
- light therapy
- chapter
- psychiatry
- oxide
- nitric
