http://hdl.handle.net/1765/10564
isbn: 978-908559-101-6

Barrett’s Esophagus: a Molecular Characterization

(Barrett-oesofagus: een moleculaire karakteristiek)


Doctoral Thesis
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(051209_Bax, Dorien Arjanne.pdf, 16.7MB)

Barrett’s esophagus is a premalignant condition that is most likely caused by gastroesophageal reflux. In the western world, about 30% of adults have reflux complaints, such as heartburn, and about 10% of reflux patients will develop Barrett’s esophagus [1]. Barrett’s esophagus is characterized by chronic inflammation, and like other chronic inflammatory lesions, it is associated with cancer development. Patients with Barrett’s esophagus have a 30 times increased risk for the development of esophageal adenocarcinoma compared to the general population. Barrett’s esophagus can progress to esophageal adenocarcinoma through the intermediate stages low-grade dysplasia and high-grade dysplasia [3]. Esophageal adenocarcinoma has a poor prognosis, the overall survival is only 15-20%.


Supervisor (promotor):

Prof. Dr. Kuipers, E.J.

The author wishes to thank:

Pfizer
AstraZeneca
Kuipers, Prof. Dr. E.J. (promotor)
Department of Gastroenterology and Hepatology, Erasmus MC
Jurriaanse Stichting
NVGE, section experimental gastroenterology
Roche Diagnostics


Keywords


Automatically Extracted Terms
  • esophagus
  • barrett
  • expression
  • adenocarcinoma
  • patient
  • epithelium
  • esophageal
  • esophageal adenocarcinoma
  • biopsy
  • dysplasia
  • protein
  • cdx 2
  • level
  • cdx 2 expression
  • sample
  • reflux
  • development
  • figure
  • chapter
  • cancer


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