Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report
January 1986
Article
pp 173-181.
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Nineteen influenza virus strains were examined for susceptibility to amantadine-HCl (AMT) and for pH-thresholds of haemagglutinin-induced haemolysis. Whereas pH-thresholds below 5.5 were not seen in AMT-resistant strains, AMT-sensitive strains showed pH-thresholds either below or above 5.5.
Keywords
- *Cell Fusion
- Amantadine/*pharmacology
- Animals
- Cell Line
- Drug Resistance
- Endocytosis
- Haplorhini
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral/physiology
- Hemolytic Plaque Technique
- Hydrogen-Ion Concentration
- Kidney
- Orthomyxoviridae/*drug effects/physiology
- Protein Conformation
Automatically Extracted Terms
- virus
- influenza
- strain
- influenza virus
- / x 31
- ph-threshold
- haemolysi
- amantadine
- t h e
- lysosomal ph
- fusion
- experiment
- assay
- virol
- susceptibility
- change
- virus titres
- virus production
- study
- semliki forest virus
