http://hdl.handle.net/1765/15032
pubmed: 8413706

Influenza-epidemie in een verpleeghuis door een virus dat niet in het vaccin was opgenomen

(An influenza epidemic in a nursing home caused by a virus not included in the vaccin)


Article
pp 1973-1977.
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In the autumn of 1992 two-thirds of the population of a nursing home in Amsterdam was vaccinated against influenza. However, in March 1993 an outbreak of an influenza like illness occurred with a morbidity rate of 49% and a mortality rate of 10%. There was sufficient serological evidence to show that the vaccine as such had induced adequate immunity. As the causative agent an influenza A/H3N2 virus was identified. The failing activity of the vaccine in this instance was apparently caused by the absence of sufficient antigen similarity between the A/H3N2 vaccine component and the epidemic virus ('vaccine mismatch').



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