The use of micro-CT to study bone architecture dynamics noninvasively
June 2006
Article
volume 3, issue 2 pp 213-219.
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High-resolution micro-CT has become a standard tool in the evaluation of bone architecture. It has recently progressed from an invasive tool for bone specimens into an in vivo tool for small animals. The combination of novel sophisticated evaluation methods, such as registration (matching) of sequential scans and computer simulation models will further evolve in vivo micro-CT into an optimal tool for small animal phenotyping and contemporary approaches for drug discovery relating to the skeleton.
Keywords
- drug effect
- nonhuman
- phenotype
- review
- computer assisted tomography
- reliability
- osteoporosis
- nuclear magnetic resonance imaging
- risedronic acid
- in vivo study
- drug mechanism
- histopathology
- positron emission tomography
- accuracy
- computer simulation
- bone remodeling
- bone turnover
- osteoarthritis
- radiation dose
- structure analysis
- three dimensional imaging
- trabecular bone
- bone density
- alendronic acid
- bisphosphonic acid derivative
- bone metabolism
- bone strength
- bone structure
- calcitonin
- cancellous bone
- bone stress
- computer model
- image reconstruction
- non invasive measurement
- parathyroid hormone
- process optimization
- selective estrogen receptor modulator
- single photon emission computer tomography
