Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
April 2009
Article
volume 41, issue 4 pp 396-398.
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Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Keywords
- article
- endothelium cell
- priority journal
- nonhuman
- angiogenesis
- protein domain
- vascularization
- embryo
- collagen
- genetic screening
- calcium binding
- developmental stage
- endothelial cell growth factor
- vasculotropin C
- zebra fish
