Modulation of toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus
May 2009
Article
| Related Files |
|---|
|
Redirect to publisher's version
(publisher's version.url.txt, 38 bytes) |
Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1β proinflammatory responses in human mononuclear cells with suppression of IL-1β mRNA transcription. Background TLR2 and TLR4 mRNA transcription was not influenced. A. fumigatus conidia induced TLR2 internalization and uptake into the phagosome with a resultant decrease in surface receptor expression. A. fumigatus hyphae, on the other hand, selectively downregulated the TLR4-mediated response. These novel immunosuppressive effects may facilitate the invasiveness of A. fumigatus.
- article
- human
- priority journal
- controlled study
- nonhuman
- drug antagonism
- immunological tolerance
- immunology
- immunomodulation
- interleukin 6
- biosynthesis
- down regulation
- interleukin 1beta
- Aspergillus fumigatus
- TLR4 protein
- conidium
- cytokine responsive element
- fungal strain
- fungus hyphae
- fungus spore
- toll like receptor 2
- toll like receptor 4
