http://hdl.handle.net/1765/17005

Genetic and Functional Analysis of Androgen Receptor Gene Mutations

(Genetische en Functionele Analyse van Mutaties in het Androgeen Receptor Gen)


Doctoral Thesis
/
Published by
Related Files
asset icon
(980612_Bruggenwirth, Henrica Theresia.pdf, 4.7MB)
asset icon
(stellingen Bruggenwirth.pdf, 0.1MB)

Nuclear hormone receptors (NHRs) are intermediary factors through which extracellular signals regulate expression of genes that are involved in homeostasis, development, and differentiation (Beato et al. '995, Mangelsdorf and Evans 1995). These receptors are characterized by a modular structure, with domains involved in transcription activation, DNA binding. hormone binding, and dimerization. The nuclear receptor super-family comprises three subfamilies of receptors, which might have emerged early during evolution (Laudet et af. 1992).


Supervisor (promotor):

Prof. Dr. Grootegoed, J.A.

The author wishes to thank:

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)


Keywords


Automatically Extracted Terms
  • receptor
  • androgen
  • mutation
  • patient
  • skin fibroblasts
  • protein
  • androgen receptor gene
  • binding
  • ar gene
  • residue
  • activation
  • hormone
  • transcription
  • expression
  • figure
  • fibroblast
  • study
  • domain
  • androgen receptor
  • phenotype


Bookmark with: