The Role of a CA Repeat Polymorphism in the Promoter Region of the Insulin like Growth Factor-I gene in Physiology and the Pathophysiology of Diabetes Mellitus
(De rol van een CA repeat polymorfisme in de promoter regio van het Insuline-achtige Groei factor-I gen in de fysiologie en in de pathofysiologie van diabetes mellitus)
2009-12-16
Doctoral Thesis
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A polymorphism in the promoter region of the IGF-I gene is amongst others related to total IGF-I serum levels, body height and type 2 diabetes. In this thesis, we investigated the influence of this polymorphism on the age-related decline, secular trend in body height, beta cell function, risk of micro-albuminuria, diabetic retinopathy and mortality. All subjects were participants of the Rotterdam Study, a population based cohort study of diseases in the elderly. We observed an age related decline in IGF-I serum levels only in subjects who were carrier of the most frequent alleles. Individuals who were non-carriers of the most frequent alleles, had the lowest serum IGF-I level and the lowest body height. Furthermore, we observed in this group in individuals with a normal glucose tolerance a decreased beta cell function. Non-carriers of the mst freqent alleles also had a higher risk to develop diabetic retinopathy, micro-albuminuria and had worse survival compared to persons who were carriers of the most frequent alleles.
Dutch Diabetes Foundation,
Novartis Farma BV,
Eli Lilly Nederland B.V.,
Servier Nederland Farma B.V,
Novo Nordisk B.V.,
Boehringer Ingelheim B.V.
- igf-i
- study
- diabetes
- level
- growth
- carrier
- allele
- glucose
- insulin
- subject
- igf-i levels
- igf-i gene
- body height
- polymorphism
- type 2 diabetes
- genotype
- 192-
- factor
- variant carriers
- glucose tolerance
