Primitive progenitor cells in human acute myeloid leukemia : studies in immunodeficient mice and in long-term bone marrow culture
(Leukemische voorlopercellen in acute myeloide leukemie)
1997-05-28
Doctoral Thesis
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Acute myeloid leukemia is a malignant clonal proliferation of immature hematopoietic cells. Leukemic blasts may express abilities for maturation to a variable degree, which leads to morphological heterogeneity. Generally the transformed leukemic stem cell is committed to the granulocytic lineage. Sometimes a predominance of blast cells from the erythroid or megakaryocytic lineage may be observed. The leukemic transformation may occur at the level of a pluripotent or a less primitive hematopoietic cell. This is apparent from the observation of clonal markers, e.g. unique cytogenetic abnormalities in single versus several blood cell lineages.
Supervisor
(promotor):
Keywords
Automatically Extracted Terms
- leukemia
- aml cells
- scid mice
- growth
- marrow
- hematopoietic
- mouse
- assay
- blood
- hematopoietic cells
- myeloid leukemia
- myeloid
- transplantation
- culture
- 5- fu
- fraction
- leukemic
- bone marrow
- factor
- cd 34
