cal, therapeutic and histo-morphological studies in primary biliary cirrhosis and primary sclerosing cholangitis
(Klinische, therapeutische en histo-morfologische studies in primaire biliaire cirrose en primaire scleroserende cholangitis)
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Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are chronic cholestatic liver diseases, biochemically characterised by an elevated serum bilirubin, alkaline phosphatase (APh) and y-glutamyl transferase (y-GT). Although PBC and PSC have their own distinctive clinical, immunological, radiological and histological features, both diseases show a necro-inflammatory process, predominantly confined to the bile ducts within the portal tracts. In most patients the disease gradually progresses and may lead to cirrhosis and liver failure. Transplantation may then be the only therapeutic option left.
- biliary cirrhosis
- sclerosing cholangitis
- ursodeoxycholic acid