http://hdl.handle.net/1765/20215

scopus: 77957664307



HFE gene mutations increase the risk of coronary heart disease in women


Article
volume 25, issue 9 pp 643-649.
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he purpose of the present study is to examine HFE gene mutations in relation to newly diagnosed (incident) coronary heart disease (CHD). In a population-based follow-up study of 7,983 individuals aged 55 years and older, we compared the risk of incident CHD between HFE carriers and non-carriers, overall and stratified by sex and smoking status. HFE mutations were significantly associated with an increased risk of incident CHD in women but not in men (hazard ratio [HR] for women = 1.7, 95% confidence interval [CI] 1.2-2.4 versus HR for men = 0.9, 95% CI 0.7-1.2). This increased CHD risk associated with HFE mutations in women was statistically significant in never smokers (HR = 1.8, 95% CI 1.1-2.8) and current smokers (HR = 3.1, 95% CI 1.4-7.1), but not in former smokers (HR = 1.3, 95% CI 0.7-2.4). HFE mutations are associated with increased risk of incident CHD in women.



Keywords


Automatically Extracted Terms
  • mutation
  • hfe mutations
  • study
  • women
  • disease
  • carrier
  • smoking
  • smoker
  • smoking status
  • non-carrier
  • incident chd
  • hemochromatosi
  • heart disease
  • level
  • heart
  • status
  • c 282y mutation
  • baseline
  • chd risk
  • smokers non-carriers hfe-carriers


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