http://dx.doi.org/10.1016/j.jneuroim.2010.04.021
scopus: cited 3 times
web of science: cited 3 times
Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells
August 2010
Article
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Myelin-laden macrophages reside within the CNS, the CSF and in the CNS-draining lymph nodes during MS and EAE, suggesting migration of these macrophages between these compartments and interaction with other cells. Since chemokines and their receptors are pivotal for leukocyte trafficking, we addressed whether myelin ingestion affects chemotaxis of mouse macrophages in vitro. Myelin ingestion enhanced expression of CCR7 and CXCR3 on macrophages and migration towards CCL21 and CXCL10. Furthermore, myelin-laden macrophages released chemoattractants resulting in enhanced migration of myeloid cells in vitro. Our data demonstrate that myelin-laden macrophages have increased motility and suggest trafficking between anatomical compartments in vivo. © 2010 Elsevier B.V.
- article
- human
- bone marrow cell
- priority journal
- controlled study
- animal experiment
- mouse
- nonhuman
- myelin
- in vitro study
- protein expression
- Cerebrospinal fluid
- Macrophages
- Multiple sclerosis
- animal cell
- central nervous system
- cerebrospinal fluid
- Cervical lymph nodes
- Immune cell trafficking
- cell interaction
- chemokine receptor CCR7
- chemokine receptor CXCR3
- gamma interferon inducible protein 10
- chemotaxis
- lymph node
- macrophage function
- macrophage migration
- secondary lymphoid tissue chemokine
