Regulation and modulation of the plasma fibrinogen level
(Regulatie en modulatie van de fibrinogeen-waarden in plasma)
1995-03-15
Doctoral Thesis
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Fibrinogen is a soluble plasma glycoprotein that, under normal circumstances, is present in human plasma at a concentration of 2-4 mg/ml (6-12 I'M). The plasma half-life is 3-4 days in humans and about 10-25 % of the total body fibrinogen is extravascularl. Fibrinogen is composed of two sets of three polypeptide chains (AOI, 86 . and 'Y) that are interconnected by disulphide bridges . The aminoterminal segments of all six chains form a central domain from which the AOI and 86 chains protrude. These aminotermini are the target of thrombin and small peptides (FPA and FP8) can be cleaved off.
Supervisors
(promotores):
The
author
wishes to thank:
Netherlands Heart Foundation,
Sanofi-Winthrop V.O.F.,
TNO
Keywords
Automatically Extracted Terms
- fibrinogen
- level
- plasma
- patient
- study
- plasma fibrinogen levels
- fibrinogen levels
- effect
- assay
- disease
- protein
- group
- phase
- smoking
- method
- fihrinogen
- factor
- polymorphism
- ticlopidine
- variation
