γδβ-thalassaemias 1 and 2 are the result of a 100 kpb deletion in the human β-globin cluster.
January 1986
Article
volume 14 pp 7017-7028.
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The DNA spanning two large deletions in the human beta-globin gene cluster (gamma beta-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100 kb of DNA in a deletion event not involving homologous or repetitive sequences.
Keywords
- Human
- Support, Non-U.S. Gov't
- Chromosome Mapping
- Multigene Family
- Thalassemia/*genetics
- Repetitive Sequences, Nucleic Acid
- 9004-22-2 (Globins)
- Globins/*genetics
- Chromosome Deletion
- *Chromosomes, Human, Pair 11
Automatically Extracted Terms
- probe
- result
- deletion
- sequence
- chromosome
- breakpoint
- cluster
- fragment
- region
- family
- p-globin
- event
- deletion event
- research
- hybridization
- globin
- rearrangement
- sph 2.5 probe
- alui family sequences
- acids research
