Differential regulation of a Thy-1 gene in transgenic mice.
January 1987
Article
pp 1492-1496.
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We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but not the endogenous gene, was suppressed. This result shows that different regulatory elements are used to express the Thy-1 gene in early and late lymphoid development.
Keywords
- Animals
- Support, Non-U.S. Gov't
- Mice
- Age Factors
- 0 (RNA, Messenger)
- *Gene Expression Regulation
- RNA, Messenger/analysis
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Crosses, Genetic
- Transcription, Genetic
- T-Lymphocytes/immunology
- 0 (Antigens, Surface)
- 0 (Antigens, Thy-1)
- Antigens, Thy-1
- Antigens, Surface/biosynthesis/*genetics
- Brain/immunology
