http://hdl.handle.net/1765/24581
http://dx.doi.org/10.1038/ng.416
pubmed: 19597492
scopus: 68149165772
http://dx.doi.org/10.1038/ng.416
pubmed: 19597492
scopus: 68149165772
Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry
August 2009
Article
volume 41, issue 8 pp 879-881.
Repository contains one file which is not publicly available
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10-11; combined RR = 1.25; combined P = 1.8 × 10-15).