Transcriptional Regulation of Multi-Gene Loci: Multi-Level Control.
April 1993
Article
volume 9, issue 4 pp 134-137.
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Recent studies indicate that different levels of control operate within multigene loci. In addition to regulatory sequences immediately flanking the genes, there are also elements that act over long distances on more than one gene. Competition for these elements among genes can influence both the level and timing of gene expression during development.
Keywords
- Animals
- Human
- Support, Non-U.S. Gov't
- Mice
- *Transcription, Genetic
- *Gene Expression Regulation
- *Regulatory Sequences, Nucleic Acid
- *Multigene Family
- Genes, Regulator/physiology
Automatically Extracted Terms
- element
- expression
- globin
- locus
- level
- acids res
- enhancer
- region
- promoter
- grosveld
- chromatin
- 13- globin gene
- transcription
- multigene loci
- effect
- control
- study
- regulation
- model
- development
