The POU factor Oct-6 is required for the progression of Schwann cell differentiation in peripheral nerves.
January 1996
Article
volume 273, issue 5274 pp 507-510.
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The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6(-/-) mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.
Keywords
- Animals
- Mice
- Molecular Sequence Data
- Base Sequence
- Gene Expression
- Animals, Newborn
- Mice, Inbred C57BL
- Cell Differentiation
- 0 (Transcription Factors)
- Recombination, Genetic
- Myelin Sheath/physiology
- Stem Cells
- 0 (Myelin P0 Protein)
- 0 (Myelin Proteins)
- Axons/ultrastructure
- 132052-52-9 (POU transcription factor Oct-6)
- Myelin P0 Protein/genetics/metabolism
- Schwann Cells/*cytology/physiology
- Sciatic Nerve/cytology/growth & development
- Transcription Factors/*genetics/*physiology
- Myelin Proteins/genetics/metabolism
